Simon Bury United Kingdom

Selcia Ltd., headquartered in Ongar, Essex, UK and with a branch in Hopkinton, Massachusetts, is a leading worldwide provider of contract research services. Selcia operates two divisions, Selcia Discovery and Selcia Radiochemistry. Whilst Radiochemistry specializes in 14C GMP radiolabelling, Selcia Discovery provides integrated small molecule drug discovery to pharmaceutical and biotech clients. Besides general medicinal chemistry and biology capabilities applicable across all target classes, Selcia Discovery has a particular strength in three unique and highly synergistic technologies: (1) medicinal chemistry on complex natural products, (2) capillary electrophoresis-based fragment and natural product screening, (3) peptidyl-prolyl isomerase targets (cyclophilins, FKBPs, Pin1, together called PPIases). Whilst relatively neglected by pharmaceutical companies in the past, understanding of the involvement of PPIases in many diseases is currently emerging. All PPIase inhibitors presently in clinical use or in development are natural products, natural product derivatives or have structures inspired by natural products.

The combination of these technologies has enabled Selcia to deliver several clinical PPIase inhibitors to clients, but has also generated IP for Selcia, which was recently demerged into a new company, Mitopharm Ltd. Mitopharm is in advanced license negotiations for a breakthrough drug in the field of acute and chronic neurodegenerative diseases. Other applications in the fields of chronic inflammatory diseases, oncology, COPD, and virus infections will be developed by Mitopharm either via investment or via joint R&D programs with pharmaceutical companies. 

Selcia Ltd

Kevin FitzGerald United Kingdom

Immune Targeting Systems is an emerging leader in the development of vaccine products that work by promoting T-cell responses against viruses and cancers (“T-cell vaccines”). The company’s lead product Flunisyn™, currently in clinical development, is a novel T-cell vaccine which aims to elicit immune protection against multiple strains of influenza. The Company’s technology also supports a product portfolio which includes Hepsyn-B, an attractive therapeutic hepatitis B vaccine and T-cell vaccines against cancers.

Keywords
Kevin FitzGerald
Immune Targeting Systems (ITS) Ltd
COO 

Dr Hans Fliri United Kingdom

Selcia Ltd., headquartered in Ongar, Essex, UK and with a branch in Hopkinton, Massachusetts, is a leading worldwide provider of contract research services. Selcia operates two divisions, Selcia Discovery and Selcia Radiochemistry. Whilst Radiochemistry specializes in 14C GMP radiolabelling, Selcia Discovery provides integrated small molecule drug discovery to pharmaceutical and biotech clients. Besides general medicinal chemistry and biology capabilities applicable across all target classes, Selcia Discovery has a particular strength in three unique and highly synergistic technologies: (1) medicinal chemistry on complex natural products, (2) capillary electrophoresis-based fragment and natural product screening, (3) peptidyl-prolyl isomerase targets (cyclophilins, FKBPs, Pin1, together called PPIases). Whilst relatively neglected by pharmaceutical companies in the past, understanding of the involvement of PPIases in many diseases is currently emerging. All PPIase inhibitors presently in clinical use or in development are natural products, natural product derivatives or have structures inspired by natural products.

The combination of these technologies has enabled Selcia to deliver several clinical PPIase inhibitors to clients, but has also generated IP for Selcia, which was recently demerged into a new company, Mitopharm Ltd. Mitopharm is in advanced license negotiations for a breakthrough drug in the field of acute and chronic neurodegenerative diseases. Other applications in the fields of chronic inflammatory diseases, oncology, COPD, and virus infections will be developed by Mitopharm either via investment or via joint R&D programs with pharmaceutical companies. 

Selcia Ltd
Chairman 

Richard Jones United Kingdom

Shield Therapeutics is an independent specialty pharmaceutical company, founded in 2008 with operations in Europe & US. Focused on the development and commercialisation of late-stage, mineral-derived hospital pharmaceuticals which address areas of high unmet medical need Shield is led by Carl Sterritt, Chief Executive Officer, an experienced senior pharmaceutical executive with a track record of successful development and commercialisation of pharmaceuticals Shield has successfully raised ~$34m to fund the development of ST10 and PT20 (developed through Phosphate Therapeutics) Lead asset – ST10: Simplifying iron replacement therapy ·         Novel oral iron-based therapy with strong IPR ·         Potential to be the first simple effective oral therapy for the treatment of iron deficiency anaemia (IDA) in inflammatory bowel disease (IBD) and non-dialysis dependant chronic kidney disease (CKD) ·         Currently in Phase III trials in patients with IDA in IBD ·         Results are expected to form the basis of a marketing authorisation application (“MAA”) in 2013.  If approved, product commercialisation could commence in 2014 ·         CKD-IDA trials to follow in 2012-2013 ·         Targets potential addressable market of $5bn, with immediate IV market currently reaching  >$1bn pa   PT20: for the treatment of hyperphosphataemia ·         Novel phosphate binder to treat hyperphosphataemia in patients with pre-dialysis and dialysis-dependent CKD ·         In-licensed from Medical Research Council - agreement signed in Q3-11 ·         Early data from in vitro and in vivo trials suggests higher specificity and efficacy than current market leaders and favourable opinion received from UK-MHRA for progression to Phase II clinical trials ·         Approximately 90% of patients with kidney failure require phosphate binder therapy at some point ·         Current market size >$1bn/yr  
Shield Therapeutics AG
CFO 

Dr Robert Mayer United Kingdom

College Hill Life Sciences is a strategic communications consultancy with over two decades of experience in advising life science organisations worldwide. Our core skill is working with clients to communicate the value of their science and innovation to key stakeholders through the most relevant channels: crafting PR, IR and design solutions that showcase each company, product or technology.

We have earned a formidable reputation for incisive board-level communications counsel. Our deep understanding of the needs and drivers of the life science industry and our entrepreneurial approach comes from our teams’ backgrounds in executive management, R&D, Government, sales & marketing, journalism and finance within the life science sector.

With a track record of delivering truly creative programmes, we focus on enhancing the value proposition for companies seeking investment, partnerships or customers. We form long-standing relationships with our clients in biotech, pharma, medical device and diagnostic companies as well as companies that enable scientific research through the supply of enabling technologies and services. We also advise venture investors and service providers.

Our approach is personal, professional and flexible, with value for money as a principle. We are passionate about our clients’ and about making a difference.

Our globally integrated and dedicated life sciences team serve clients around the world from our bases in London, Manchester, Munich, Boston and Sydney.

Dr Robert Mayer
College Hill
Account Director / General Manager 

Mr Tim Watson United Kingdom

College Hill Life Sciences is a strategic communications consultancy with over two decades of experience in advising life science organisations worldwide. Our core skill is working with clients to communicate the value of their science and innovation to key stakeholders through the most relevant channels: crafting PR, IR and design solutions that showcase each company, product or technology.

We have earned a formidable reputation for incisive board-level communications counsel. Our deep understanding of the needs and drivers of the life science industry and our entrepreneurial approach comes from our teams’ backgrounds in executive management, R&D, Government, sales & marketing, journalism and finance within the life science sector.

With a track record of delivering truly creative programmes, we focus on enhancing the value proposition for companies seeking investment, partnerships or customers. We form long-standing relationships with our clients in biotech, pharma, medical device and diagnostic companies as well as companies that enable scientific research through the supply of enabling technologies and services. We also advise venture investors and service providers.

Our approach is personal, professional and flexible, with value for money as a principle. We are passionate about our clients’ and about making a difference.

Our globally integrated and dedicated life sciences team serve clients around the world from our bases in London, Manchester, Munich, Boston and Sydney.

Mr Tim Watson
College Hill
LinkedIn logo Junior Account Director