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Virometix is a privately held young innovative Swiss Biotech company developing a new class of vaccines, which should overcome limitations of current biological vaccines in terms of safety, efficacy, speed, stability and manufacturing cost. Virometix Synthetic Virus-Like Nanoparticle (SVLP) technology platform offers the following value propositions:

Safety. Virometix SVLP-based vaccines avoid the use of life pathogens and the safety concerns associated with the biological manufacturing processes used for conventional vaccines.

Quality. SVLPs are based on a proprietary lipopeptide self-assembly process that leads to atomically defined nanoparticles with a constant size and number of lipopeptide monomers per particle, which increases the specificity and quality of the elicited immune response and assures lot-to-lot consistency.

Efficacy. SVLPs efficiently deliver antigens to antigen presenting cells for optimal B- and T-cell responses and induce antibodies that bind with very high affinity to the native target antigen.

Convenience. SVLPs do not require sonication, refolding, extrusion or similar processes. SVLPs can be prepared by simply dissolving freeze-dried lipopeptide monomers in a buffer suitable for injection shortly before use.

The protective potential of Virometix nanoparticles has been demonstrated for various targets in in vitro and in vivo. Virometix currently develops vaccines for infectious diseases and cancer and offers collaborative research and licensing partnerships for selected vaccines in these areas, and licensing opportunities for selected areas outside Virometix core focus.

BerGenBio AS develops novel cancer therapeutics against highly invasive and drug resistant tumors; its R&D is directed towards targeting the tumor microenvironment, EMT and cancer stem cells. Our lead program BGB324 is a first in class Axl inhibitor will enter Ph1 in January 2013 and has shown preclinical activity in many cancers, including AML, NSCLC, breast, pancreatic and melanoma.

The company is built on proprietary state-of-the-art RNAi technology dedicated to identifying and validating novel cancer targets, other programs are in the drug discovery and lead optimization stages.

The company located in Bergen, Norway. It is funded by a syndicate of Norwegian investors and seeking qualified co-investors for a €12m series B at YE 2012.

Scancell is an AIM listed UK based company developing novel therapeutic vaccines for the treatment of cancer based on its groundbreaking ImmunoBody® and Moditope™ technology platforms. Scancell’s first cancer vaccine SCIB1 is a DNA vaccine being developed for the treatment of melanoma and is in Phase 2 clinical trials.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be administered to a patient, stimulating an immune response. Effective cancer vaccines need to target dendritic cells to stimulate both parts of the cellular immune system; the helper cell system where inflammation is stimulated at the tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they cannot specifically target dendritic cells in vivo. Several groups have demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing them with tumour antigens and re-infusing them. However, this procedure is patient specific, time consuming and expensive. Scancell has developed its breakthrough patent protected ImmunoBody® technology to overcome these limitations.

The Immunobody® technology can be adapted to provide the basis for treating any tumour type and may also be of potential utility in the development of vaccines against hepatitis, HIV and other chronic infectious diseases.

Scancell has also identified and patented a series of modified epitopes that stimulate the production of killer CD4 that destroy tumours without toxicity. The Moditope™ platform could have a profound effect on the way that cancer vaccines are developed.