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Launched in 2007 and backed by Santé Ventures, Terapio is a biopharmaceutical company developing clinical applications based on the naturally-occurring RLIP76 protein. RLIP76 is a membrane-associated cellular transport protein that is an integral part of the cell’s normal process of removing toxic metabolites formed by oxidative insults. However, in cases of elevated oxidative stress, such as occurs with exposure to radiation and chemical toxins, the endogenous RLIP76 system can be overwhelmed, leading to cell death. Supplementing cellular levels of RLIP76 through exogenous administration of Terapio’s liposomal formulation of the RLIP76 protein promotes protection by relieving this cellular stress and allows recovery by tissue cells. This mechanism of action has broad applicability to a variety of additional clinical indications, including the treatment of the toxic side effects of therapeutic radiation and chemotherapy in oncology patients and CNS diseases – a key part of Terapio’s commercial pipeline.

For biodefense applications, Terapio has accumulated a large body of data demonstrating that the protein is effective in protecting and rescuing animals exposed to otherwise lethal exposures of whole body radiation. Therefore, the company is pursuing the prevention and treatment of Acute Radiation Syndrome (ARS) as a lead indication. No effective countermeasures for ARS exist today, making this a highly unmet need.

Terapio has performed multiple 30-day survival studies with the RLIP76 protein in animal models of ARS and demonstrated that administered either before and/or after exposure to lethal doses of radiation results in greater than 90% survival of treated animals, versus 20% survival of controls.

Terapio is seeking a lead or syndicate investors to participate with Santé Ventures in Terapio’s Series B financing. Terapio plans at least $10M in Series B financing where Santé Ventures, the Series A lead investor, will participate on a pro rata basis. The use of proceeds for Series B will be primarily used for drug development, preclinical and nonclinical programs, and regulatory activities required to fund the company to the valuation inflection point associated with completing the pivotal nonhuman primate efficacy trial under the FDA Animal Rule.

Astex Pharmaceuticals is dedicated to the discovery and development of novel small molecule therapeutics with a focus on oncology.  The Company is developing a proprietary pipeline of novel therapies and is creating de-risked products for partnership with leading pharmaceutical companies.  Astex Pharmaceuticals developed Dacogen® (decitabine) for Injection and receives significant royalties on global sales.

For more information about Astex Pharmaceuticals, Inc., please visit http://www.astx.com.

Astex Pharmaceuticals is dedicated to the discovery and development of novel small molecule therapeutics with a focus on oncology.  The Company is developing a proprietary pipeline of novel therapies and is creating de-risked products for partnership with leading pharmaceutical companies.  Astex Pharmaceuticals developed Dacogen® (decitabine) for Injection and receives significant royalties on global sales.

For more information about Astex Pharmaceuticals, Inc., please visit http://www.astx.com.

Immune Design is a privately held biotechnology company based in Seattle, Washington and formed in 2008 to bring together some of the world’s leaders in the field of immunology, and their technologies, to develop therapeutic vaccines for the treatment of infectious and malignant disease. The company’s scientific founders are Dr. David Baltimore (Past President of Caltech, Rockefeller University, and the Whitehead Institute and the Co-Recipient of the 1975 Nobel Prize in Physiology or Medicine), Dr. Steven Reed (Past Co-founder and CSO of Corixa and Founder/CEO of the Infectious Diseases Research Institute), and Dr. Larry Corey (President and Director of the Fred Hutchinson Cancer Research Center and Professor of Medicine and Laboratory Medicine at the University of Washington). To date Immune Design has raised approximately $52 million from The Column Group, Alta Partners, Versant Ventures, and Proquest.  
Immune Design leverages its unique vaccine technologies to precisely control the activation and context of antigen presentation by dendritic cells in order to shape the desired adaptive immune response.  The first technology is a novel adjuvant for recombinant protein antigen (rP)-based vaccines comprising Glucopyranosyl Lipid A (GLA), a synthetic TLR4 agonist, formulated in a stable 2% oil-in-water emulsion (SE). Adjuvants can play an important role in vaccine therapies by stimulating the immune system's response to the target antigen. GLA is the first ‘designer adjuvant’ and was developed by Immune Design co-founder Dr. Steve Reed.  To date GLA-SE has been safely administered in over 300 human subjects.   

Our second vaccine platform is a novel lentivirus-based vector, ID-LV (Immune Design-Lentiviral Vector). The prototype of ID-LV was developed by Immune Design co-founder, Dr. David Baltimore. ID-LV is unique in that it can stimulate the body’s own dendritic cells (DCs), the “sentinels” of the immune system, to produce any, and importantly, multiple antigens of interest in the same product configuration, effectively orchestrating the human immune system to respond to targeted diseases.  Immune Design’s ID-LV and GLA-SE vaccine technologies are immunologically synergistic, as documented in animal models, and thus, have the potential to be used both alone and in combination to create the next generation of vaccines for diseases with unmet medical need.

Northern Biotechnologies has raised $1.5M in round "a" private funding. Northern is seeking commercialization and investment partnerships to continue the development of additional anti-bacterial, anti- viral and anti-fungal applications of our technology which require additional testing, proof of concept and commercialization partners.

Northern Biotechnologies is pioneering the commercialization of an innovative, long lasting, therapeutic anti-microbial technology that has significant applications in the Human Health Care arena. Infectious disease control and prevention

can be revolutionized by integration of our cost saving technology. Issued Patents and proprietary production IP offer a stable platform for growth and partnership into all human related applications of the technology. A unique feature of the technology is its extended protection of 1-3 days through each application. Additionally, the physical method of pathogen destruction prevents formation of resistant strain types, in contrast to existing technologies that rely on metabolic action for kill. Testing shows high performance anti-bacterial, anti-fungal and anti- viral functioning in various direct, topical, and wound care, nasal/ oral and related dosing mechanisms of the technology. We are in process with the first New Drug Application for antiseptic hand wash, and are looking for partners to pursue additional drug approvals in specific markets.

Existing product branding in the Human market is Prefense hand sanitizer and wipes. In addition to human applications, Northern holds over twenty-five global patents for anti-microbial water filtration using our technology. We also hold EPA registrations for persistent antimicrobial filter media. Significant opportunity exists in the technology used as a multi surface sanitizer for all levels of food production. Other existing product lines and cash flow are in place from additional internally developed technologies including high performance filtration medias, biotech remediation and process technologies used in petroleum, agricultural, and industrial processing. Northern also holds nationally placed consumer and professional brand lines of "green probiotic" cleaning products based on our IP and manufacturing base. Additionally, our cGMP contract packaging division sells our proprietary formulations to many national brands in a variety of markets. Company management is made of a diverse team with the experience and drive required to steer strong growth and relationships with partner companies. 

Eniluracil/5-FU/leucovorin has promise to produce therapeutic advantages over iv 5 FU and capecitabine

Eniluracil inactivates dihydropyrimidine dehydrogenase (DPD), thereby preventing the formation of α fluoro-β-alanine (F-BAL), and conferring 100% oral bioavailability and a 5 hr half life on 5 fluorouracil (5 FU).  An open-label Eniluracil, 5-FU and leucovorin vs. capecitabine (4:3 randomization) Phase II trial for metastatic breast cancer is in progress. Study drugs are administered orally for 1st- or 2nd-line treatment for metastatic disease in patients previously treated with an anthracycline and a taxane. Arm 1: eniluracil/5-FU/leucovorin administered once/week for 3 weeks/4 weeks. Arm 2: capecitabine (1000 mg/m2) taken bid for 14 days/21days.  Arm 2 patients with disease progression could crossover to take eniluracil/5-FU/leucovorin in Arm X.  Eniluracil/5-FU/leucovorin has been active and well tolerated in both Arm 1 and Arm X.  The primary endpoint, progression-free survival, will be determined approximately 7.5 months after the trial is enrolled with 140 evaluable patients, expected in 2Q 2013.